Most shooting diagrams show nice broadside and level shots and the 2D representation works pretty well. The key structure is directly behind the shot placement location. This all changes with the orientation of the animal as they are 3D and not just 2D. The nice heart/shoulder broadside shot becomes much more of a midbody shot for a hog quartering severely away, for example. Midbody shots often look quite bad, like the shooter was just trying to shoot COM, but if the hog is quartered away, it may be the perfect shot placement. I am happy to have nice broadside shots, but it seems that most of the time, the hogs I shoot are quartered toward or away from me, some severely, sometimes because they are on the move.
What I learned then is that if you are going to shoot based on shot placement externally, then you must always consider placement, trajectory, and penetration damage. Where you hit on the outside of the hog has to have the trajectory to pass through the critical vital structures and the penetration to actually pass through them in order to damage them by direct contact or hydrostatic shock. Think of where the organ/structure is inside of the body that you are trying to hit and aim for that location, not just external landmarks.
I do like CNS shots, not because they preserve more of the meat, but because hogs don't get run and don't get up after CNS shots. In my experience, hogs that run virtually never run to the truck. They run just about everywhere else but the truck, but especially (it seems) into thickets, briars, poison ivy, and ravines if they can make it to them. I had a devil of a time finding this 180 pounder and he only ran about 50 or 60 yards. It was a pretty good broadside heart/lung shot, but I had to use loppers to get to him.